The Course

From metabolic flux analysis to biological process control: a digest with worked examples and real-life applications


    Metabolic networks, and metabolic flux analysis
  • Dynamic modeling of ecological and biological systems
  • Compartmental systems
  • Linear and nonlinear parameter estimation, parameter identifiability and experiment design
  • Design of software sensors (state estimation)
  • Optimal, optimizing and predictive control
  • Matlab worked examples and real-case applications in various fields (water treatment, anaerobic digestion, food science and predictive microbiology, etc.)

Course organization

The course is organized in collaboration with KUL and UCL in 4 sessions of 6 hours each (July 1-2, and July 8-9, 2019).


UCLouvain Logo Pos RVB

Target audience

Master students and doctorate researchers interested in mathematical modeling, estimation and control of biological systems and bioprocesses in a wide sense.


Some background knowledge on linear algebra, differential equations, and system dynamics are required in several parts of the course.

Some prior knowledge of a high-level programming language such as Matlab, Octave, Scilab, may be useful.

Summer Course Package

This package covers the time period of July 1rst to July 10th and includes the mini-courses, the conference, technical and cultural activities on the week-end (6-7 July), lodging and catering, please see the leaflet for further information.


The Lecturers

Jan Van ImpePicture1

Prof. Jan F.M. Van Impe obtained an MSc degree in electrical and mechanical engineering from the University of Gent in 1988, and a PhD in applied sciences from the KU Leuven in 1993. Thereafter, he founded the BioTeC (Chemical and Biochemical Process Technology and Control) research group, spanning research in predictive microbiology, biotechnology, environmental processes, and systems biology and control.

He (co-)authored more than 600 full papers in international journals and international conference proceedings, and edited several books in these areas. Over the period 1998-2018 he (co)supervised over 60 PhD theses. In 2018, he was awarded a honorary doctorate (honoris causa) by ULB.


Georges Bastin


Prof. Georges Bastin is a specialist in the control of complex dynamic systems. He is particularly interested in modeling and control of compartmental dynamical systems, network systems and systems governed by conservation laws (partial differential equations). He has studied a variety of applications ranging from biotechnology to free-surface hydraulic systems, road networks, communications and robotics. Georges Bastin has always had the constant concern to develop academic and industrial partnerships by being involved in numerous contracts or research programs. He is the author of more than 300 referenced publications (book chapters, articles of international journals and international conferences). He is co-author of 2 books, and several lecture notes. In 2012, he was awarded a honorary doctorate (honoris causa) by Grenoble INP.

Alain Vande Wouwer

alainProf. Alain Vande Wouwer graduated in Electrical Engineering from the Faculté Polytechnique de Mons (Belgium) in 1988, and obtained a PhD in Applied Sciences from the same university (in collaboration with Stuttgart University for a European doctorate degree) in 1994. This latter year, he also achieved a postdoctoral stay in the Mechanical Engineering Department of Université Laval (Quebec). Since then, he has been working at the University of Mons, where he is currently the head of the Control Department. For the last 20 years, he has focused most of his research on numerical simulation, bioprocess modeling, estimation and control, developing collaborations with industries and international research groups. In recent years, he also engaged in research on flight control of unmanned aerial vehicles. Alain Vande Wouwer was (co-)supervisor of 20 PhD theses, and co-author of 2 books and about 100 journal articles.